Population
Primary porcine blood macrophage cell cultures and Yorkshire pigs (30 to 35 kg)
Comparison
Infection with African swine fever virus 9GL… vs Infection with revertant virus or parental virus
Design
Preclinical
Follow-up
30 days postinfection for pigs
Authors
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Supports 9GL deletion for ASFV attenuation in swine; leaves open live-attenuated vaccine translation pending further studies.
Deletion of the 9GL gene in African swine fever virus attenuates the virus in swine and protects against lethal challenge, suggesting potential as a live-attenuated vaccine.
Lewis et al. (2000) studied this question.
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