Why the study?
Is central sympathetic outflow increased in patients with cirrhosis and ascites compared to those without ascites and healthy volunteers?
Population
34 subjects: 11 patients with cirrhosis and ascites, 8 patients with cirrhosis but without ascites, 7…
Design
Cross-sectional
Authors
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Increased sympathetic outflow may drive ascites in cirrhosis; hypothesis-generating and should not yet change practice.
Is central sympathetic outflow increased in patients with cirrhosis and ascites compared to those without ascites and healthy volunteers?
Elevated plasma norepinephrine concentrations in patients with cirrhosis and ascites are driven by increased central sympathetic outflow, which is not seen in cirrhotic patients without ascites.
Floras et al. (1991) studied this question.
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