Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 8, 2022Journal of Clinical MedicineOpen Access

Effects of Toxic Lithium Levels on ECG—Findings from the LiSIE Retrospective Cohort Study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Few studies have explored the impact of lithium intoxication on the heart.

Does lithium intoxication cause significant ECG changes such as heart rate reduction or QT prolongation in affected patients?

Population

1136 patients included in the LiSIE study (92 with 112 episodes of lithium intoxication)

Comparison

ECGs during lithium intoxication vs before and/or after intoxication

Design

Retrospective cohort study

Authors

PTPetra TruedsonUmeå UniversityMOMichael OttUmeå UniversityKLKrister LindmarkKarolinska University Hospital

Discussion

Loading...

Member takes

Implication

May identify cardiac effects in lithium intoxication; leaves open need for prospective monitoring studies.

Structured PICO

Does lithium intoxication cause significant ECG changes such as heart rate reduction or QT prolongation in affected patients?

P
Population
1136 patients in the LiSIE retrospective cohort study, of which 92 patients experienced 112 episodes of lithium intoxication.
I
Intervention
Lithium intoxication (toxic lithium levels)
C
Comparator
Reference ECGs from the same patients before and/or after the lithium intoxication episode
O
Outcome
Electrocardiogram (ECG) changes, specifically heart rate and QTc intervalsurrogate

Cite This Study

Truedson et al. (2022) studied this question.

synapsesocial.com/papers/6a7243a02163a0a01bc60599https://doi.org/10.3390/jcm11195941
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrocardiographic Abnormalities as Predictors for Over-Range Lithium Levels2004 · 31 citations
  2. 2Lithium in the Treatment of Mood Disorders1994 · 245 citations