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Identify biochemical markers capable of predicting insulin resistance in nonobese women with polycystic ovary syndrome.

August 1, 2003The Journal of Clinical Endocrinology & MetabolismOpen Access

Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with Polycystic Ovary Syndrome

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Identify biochemical markers capable of predicting insulin resistance in nonobese women with polycystic ovary syndrome.
Assessed 16 nonobese women with polycystic ovary syndrome using a euglycemic hyperinsulinemic clamp to quantify steady-state glucose disposal rates.
Measured fasting and oral glucose tolerance test insulin concentrations alongside serum levels of sex hormone-binding globulin, leptin, and adiponectin.
Eight of 16 participants demonstrated insulin resistance (glucose disposal < 8.5 mg/kg·min), which correlated negatively with body mass index (P = 0.01), waist-to-hip ratio (P = 0.01), and fasting insulin (P = 0.003).
Stepwise regression analysis identified the glucose-to-insulin ratio as the strongest independent predictor of insulin resistance (R² = 0.61).
Plasma adiponectin correlated positively with glucose disposal (P = 0.043) and negatively with waist-to-hip ratio (P = 0.024), while body mass index was the sole independent predictor of sex hormone-binding globulin levels (R² = 0.73, P = 0.003).

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Implication

Clinical study reveals that the fasting glucose-to-insulin ratio outperforms adiponectin and SHBG in predicting insulin resistance in nonobese women with PCOS, highlighting an accessible screening...

Cite This Study

Ducluzeau et al. (2003) studied this question.

synapsesocial.com/papers/6a724641b27f15817827fd2e https://doi.org/10.1210/jc.2003-030219

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Implication

Clinical study reveals that the fasting glucose-to-insulin ratio outperforms adiponectin and SHBG in predicting insulin resistance in nonobese women with PCOS, highlighting an accessible screening...

Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with Polycystic Ovary Syndrome

Key Points

Discussion

Implication

Cite This Study

Glucose-to-Insulin Ratio Rather than Sex Hormone-Binding Globulin and Adiponectin Levels Is the Best Predictor of Insulin Resistance in Nonobese Women with Polycystic Ovary Syndrome

Key Points

Discussion

Implication

Cite This Study

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