Why the study?
Does monocrotaline-induced pulmonary hypertension cause biventricular remodelling of myosin and collagen in Sprague-Dawley rats?
Population
Sprague-Dawley (SD) rats
Comparison
Subcutaneous injection of monocrotaline vs Control rats
Design
Preclinical
Follow-up
4 weeks
Authors
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Provides mechanistic insights into biventricular remodeling in experimental PH; leaves open translation to human right heart failure.
Does monocrotaline-induced pulmonary hypertension cause biventricular remodelling of myosin and collagen in Sprague-Dawley rats?
Monocrotaline-induced pulmonary hypertension leads to biventricular remodelling of contractile and non-contractile proteins, providing insights into the pathophysiology of cardiac hypertrophy.
Ishikawa et al. (1992) studied this question.
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