Why the study?
Does chronic infusion of dobutamine produce cardiovascular and metabolic conditioning effects similar to exercise training in chronically instrumented dogs?
Population
Chronically instrumented dogs
Comparison
Dobutamine infusion or treadmill exercise for 2… vs Normal saline infusion for 2 hours a day, 5 days…
Design
Preclinical
Follow-up
5 weeks
Authors
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Suggests sympathetic stimulation contributes to conditioning; hypothesis-generating in dogs and leaves open human translation.
Does chronic infusion of dobutamine produce cardiovascular and metabolic conditioning effects similar to exercise training in chronically instrumented dogs?
Chronic dobutamine infusion produces cardiovascular and metabolic conditioning effects comparable to exercise training in a canine model, suggesting sympathetic stimulation plays a role in physical conditioning.
Liang et al. (1979) studied this question.
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