Population
Brown fat cells
Comparison
Norepinephrine perfusion, alpha-agonists, and Ca… vs Unstimulated cells, beta-agonist CGP-12177A, and…
Design
Preclinical
Authors
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Identifies norepinephrine-activated cation channels in rodent brown adipocytes; leaves open relevance to human thermogenesis or metabolism.
The sustained inward current in brown fat cells induced by norepinephrine is mediated by alpha(1)-adrenergic receptor activation of nonselective cation channels, likely via increased intracellular calcium.
Koivisto et al. (2000) studied this question.
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