Why the study?
Does salt intake affect blood pressure and platelet activity in Black African hypertensive patients compared to normotensive subjects?
Does salt intake affect blood pressure and platelet activity in Black African hypertensive patients compared to normotensive subjects?
In Black African patients, essential hypertension and salt sensitivity are associated with exaggerated in vitro and in vivo platelet activity.
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Salt sensitivity may heighten thrombotic risk via platelet activation in Black African hypertensives; leaves open whether salt restriction alters outcomes.
Black essential hypertensive patients with a mean arterial pressure of 125 +/- 3 mm Hg (mean +/- SEM), and age and sex matched normotensive subjects with a mean arterial pressure of 89 +/- 2 mm Hg were studied under baseline conditions, after five days of salt restriction and after five days of salt loading. Salt sensitivity was defined as an increase of mean blood pressure exceeding 5% when progressing from low to high sodium intake. In vitro platelet responsiveness was assessed by aggregometry, and in vitro platelet activity by estimation of beta-thromboglobulin (BTG) in plasma and thromboxane B2 (TXB2) excretion rate. Salt sensitivity was present in 66% of hypertensive and 55% of the normotensive subjects. An increased platelet aggregability to ADP (25%), to epinephrine (34%) and to collagen (12%) was found in parallel with an increased in vivo platelet activity (BTG increased by 55% and TXB2 by 18%) in the hypertensives. All changes were significantly exaggerated in the salt sensitive as compared to salt resistant hypertensive patients.
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Somova et al. (1993) studied this question.
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