Key result
Circulating plasma endothelin-1 levels are significantly increased in Black hypertensive patients compared with White hypertensive patients, suggesting its importance in this population.
Endothelin-1 overexpression may contribute to the pathogenesis of salt-sensitive, low-renin essential hypertension in black patients.
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Does not support ET-1–targeted therapy in Black hypertensives; leaves open mechanistic and therapeutic roles pending prospective trials.
Adviye Ergul (2000) conducted a review in Hypertension in Black patients. Circulating plasma endothelin-1 levels are significantly increased in Black hypertensive patients compared with White hypertensive patients, suggesting its importance in this population.
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