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March 17, 2021Asian Cardiovascular and Thoracic Annals

Outcomes following coronary artery bypass surgery in diabetic treatment sub-groups. A propensity matched analysis of >7000 patients over 18 years

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Why the study?

EuroSCORE II incorporates insulin-controlled diabetes but omits tablet-controlled diabetes, and differences in adverse clinical outcomes after CABG between these groups are poorly established.

Does the type of diabetes treatment (insulin vs. tablet) affect short and longer term mortality and morbidity in patients undergoing isolated first-time CABG compared to non-diabetics?

Population

8241 patients undergoing isolated first-time coronary artery bypass graft surgery

Comparison

Insulin-controlled diabetes vs tablet-controlled diabetes vs non-diabetic patients

Design

Propensity-matched study

Authors

YHYama HaqzadLeeds General InfirmaryJHJames HobkirkBritish Heart FoundationPAPriyadharshanan AriyaratnamLeeds General Infirmary

Discussion

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Implication

May support refining EuroSCORE II to include tablet-controlled diabetes in CABG; leaves open prospective validation.

Structured PICO

Does the type of diabetes treatment (insulin vs. tablet) affect short and longer term mortality and morbidity in patients undergoing isolated first-time CABG compared to non-diabetics?

P
Population
8,241 patients undergoing isolated first-time coronary artery bypass graft surgery between April 1999 and April 2017 (23.5% diabetics and 76.5% non-diabetics)
I
Intervention
Insulin-controlled diabetes or tablet-controlled diabetes
C
Comparator
Non-diabetic patients
O
Outcome
Short and longer term mortality and morbidityhard clinical

Both insulin- and tablet-controlled diabetes are independent risk factors for distinct adverse outcomes after CABG, highlighting the need for improved risk stratification and post-operative cardiovascular risk management.

Cite This Study

Haqzad et al. (2021) studied this question.

synapsesocial.com/papers/6a727e0df44fa9f079dff52dhttps://doi.org/10.1177/0218492321999551

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetes and survival after coronary artery bypass grafting: comparison with an age- and sex-matched population2009 · 38 citations
  2. 2Coronary artery bypass surgery compared with percutaneous coronary interventions in patients with insulin-treated type 2 diabetes mellitus: a systematic review and meta-analysis of 6 randomized controlled trials2016 · 47 citations
  3. 3Is there a role for HbA1c in predicting mortality and morbidity outcomes after coronary artery bypass graft surgery?: Table 1:2013 · 74 citations
  4. 4Association of Elevated Pre‐operative Hemoglobin A1c and Post‐operative Complications in Non‐diabetic Patients: A Systematic Review2017 · 40 citations
  5. 5EuroSCORE II2012 · 2,988 citations