Why the study?
Does insulin-dependent diabetes mellitus alter baseline ANF levels and the ANF and sodium excretion response to an acute saline load?
Population
30 subjects including 9 normotensive controls, 8 normotensive insulin-dependent diabetics, 7 hypertensive…
Comparison
Saline infusion during a euglycaemic glucose… vs Non-diabetic controls
Design
Case-control
Follow-up
90 minutes
Authors
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Blunted ANF and natriuretic response to saline in IDDM may impair sodium handling; hypothesis-generating for diabetic hypertension mechanisms.
Does insulin-dependent diabetes mellitus alter baseline ANF levels and the ANF and sodium excretion response to an acute saline load?
Insulin-dependent diabetics exhibit higher baseline ANF levels and an impaired ANF and sodium excretion response to an acute saline load compared to non-diabetic controls.
Opocher et al. (1989) studied this question.
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