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March 1, 1990Diabetes

Role of Insulin and Atrial Natriuretic Peptide in Sodium Retention in Insulin-Treated IDDM Patients During Isotonic Volume Expansion

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Why the study?

Does hyperinsulinemia in IDDM patients impair natriuretic response and ANP stimulation during isotonic volume expansion?

Population

Normotensive and hypertensive insulin-dependent diabetes mellitus subjects with no clinical features of…

Comparison

Saline infusion during euglycemia, with… vs Nondiabetic normotensive and hypertensive…

Design

Other

Follow-up

90 minutes

Authors

RTRoberto TrevisanUniversity of BergamoPFPaola FiorettoUniversity of PaduaASAndrea SempliciniUniversity of Padua

Discussion

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Implication

Impaired natriuresis in IDDM may promote sodium retention; leaves open hyperinsulinemia's role in hypertension and requires prospective confirmation.

Structured PICO

Does hyperinsulinemia in IDDM patients impair natriuretic response and ANP stimulation during isotonic volume expansion?

P
Population
Normotensive and hypertensive insulin-dependent diabetes mellitus (IDDM) subjects with no clinical features of diabetic nephropathy, and control groups of normotensive and hypertensive nondiabetic subjects.
I
Intervention
Saline infusion (2 mmol.kg-1.90 min-1) during euglycemia, with subcutaneous insulin infusion (15 mU.kg-1.h-1) in IDDM subjects.
C
Comparator
Nondiabetic normotensive and hypertensive subjects receiving saline infusion.
O
Outcome
Sodium excretion and plasma atrial natriuretic peptide (ANP) concentrations during saline challenge.surrogate

Hyperinsulinemia in IDDM patients leads to increased proximal tubule sodium reabsorption and impaired ANP response, contributing to sodium retention and potentially hypertension.

Cite This Study

Trevisan et al. (1990) studied this question.

synapsesocial.com/papers/6a1bf6471567d2fc4d5f551ahttps://doi.org/10.2337/diab.39.3.289

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion1990 · 20 citations
  2. 2Atrial natriuretic factor in hypertensive and normotensive insulin-dependent diabetics1989 · 5 citations
  3. 3Secretion of Atrial Natriuretic Peptide in Patients with Non-Insulin-Dependent Diabetes Mellitus and Effect of Autonomic Neuropathy on it1989
  4. 4Defective Regulation and Action of Atrial Natriuretic Peptide in Type 2 Diabetes2002 · 33 citations
  5. 5Insulin blunts the natriuretic action of atrial natriuretic peptide in hypertension.1994 · 18 citations