What does this research mean for the field?

Hyperinsulinemia in insulin-dependent diabetes mellitus (IDDM) patients causes sodium retention by increasing proximal tubule sodium reabsorption and impairing the atrial natriuretic peptide (ANP) response to volume expansion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1990Diabetes

Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion

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Why the study?

Does hyperinsulinemia in IDDM patients impair natriuresis and ANP response during isotonic volume expansion compared to nondiabetic controls?

Population

Normotensive and hypertensive subjects with insulin-dependent diabetes mellitus with mean duration of 7-8…

Comparison

Saline infusion during euglycemia, with IDDM… vs Nondiabetic normotensive and hypertensive…

Follow-up

90 minutes

Authors

RTR. Trevisan PFPaola FiorettoUniversity of Padua ASA. Semplicini

Discussion

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Implication

Impaired natriuresis may promote sodium retention in IDDM; leaves open insulin-ANP interactions as therapeutic targets pending prospective studies.

Structured PICO

Does hyperinsulinemia in IDDM patients impair natriuresis and ANP response during isotonic volume expansion compared to nondiabetic controls?

Population

Normotensive and hypertensive subjects with insulin-dependent diabetes mellitus (IDDM) with mean duration of 7-8 years and no clinical features of diabetic nephropathy, alongside normotensive and hypertensive nondiabetic control subjects.

Intervention

Saline infusion (2 mmol.kg-1.90 min-1) during euglycemia, with IDDM subjects receiving a subcutaneous insulin infusion (15 mU.kg-1.h-1).

Comparator

Nondiabetic normotensive and hypertensive control subjects receiving the same saline infusion.

Outcome

Sodium excretion and plasma atrial natriuretic peptide (ANP) concentrations in response to saline challenge.surrogate

Hyperinsulinemia in IDDM patients leads to increased proximal tubule sodium reabsorption and an impaired ANP response, contributing to sodium retention regardless of hypertension status.

Cite This Study

Trevisan et al. (1990) studied this question.

synapsesocial.com/papers/6a1bf6471567d2fc4d5f5519 https://doi.org/10.2337/diabetes.39.3.289

Topics

Hypertension management

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Implication

Impaired natriuresis may promote sodium retention in IDDM; leaves open insulin-ANP interactions as therapeutic targets pending prospective studies.

Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Role of insulin and atrial natriuretic peptide in sodium retention in insulin-treated IDDM patients during isotonic volume expansion

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider