Evaluation of Pharmacological Aspirin Resistance and their Association with Gender and age in patients with Cardiovascular Disease

Background: Atherosclerosis is widely known to increase the risk of developing ischemic vascular events such as angina, transient ischemic attack, myocardial infarction and ischemic strokes. By using various methodologies aspirin resistance ranges from 0.8 to 70.1 %. Objective: The objective of current study was evaluation of pharmacological aspirin resistance and their association with gender and age in patients with cardiovascular disease Methodology: The study design was cross sectional, done at the Department of Pharmacology, Bacha Khan Medical College, Mardan for duration of one year from January 2021 to January 2022. Chrono-Log Aggregometer (''Chrono-log, Havertown, Pa., USA'') was used to study platelet aggregation utilizing Arachidonic acid of 0.5mM as an agonist. All the analysis of data was carried out by employing IBM SPSS version 24. Results: In the current research, a total of 350 patients were enrolled. There were 238 (68%) males and 112 (32%) females. Based on the status of aspirin resistance, 51 (14.57%) participants show aspirin resistance. In the current study, statistically no significant association of aspirin resistance was observed with both age and gender (p˃.05). Conclusion: According to our findings, aspirin resistance is a growing concern in individuals with cardiovascular disease which might lead to failure of treatment and substantial side effects. There might be a variety of probable reasons linked to numerous biochemical and demographic factors, such as age and sex. To investigate mechanistic causes and clinical consequences of this phenomenon, more research with a large sample size is needed.