Key result
Aspirin resistance was associated with a significantly higher atherosclerotic burden, with a median Gensini score of 80.5 compared to 45 in aspirin-sensitive patients.
Why the study?
Does aspirin resistance associate with increased extent and severity of coronary atherosclerosis in patients with suspected or known CAD?
Observational (n=100)
Does aspirin resistance associate with increased extent and severity of coronary atherosclerosis in patients with suspected or known CAD?
Absolute Event Rate: 80.5% vs 45%
p-value: p=<0.001
Aspirin resistance is independently associated with a higher atherosclerotic burden and increased rates of prior PCI and stent restenosis in patients with coronary artery disease.
Aspirin resistance may identify higher-risk CAD patients; leaves open whether testing or adjusted therapy improves outcomes.
OBJECTIVE: Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of human morbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondary protection in atherothrombotic diseases and complications. The aim of the present study was to analyze the effect of aspirin resistance on the extent and severity of atherosclerosis. METHODS: One hundred patients who underwent coronary angiography with suspected or known coronary artery disease and were using aspirin were enrolled in the study. RESULTS: Of these 100 patients, 30 (8 female and 22 male) formed the aspirin-resistant group (ARG), and 70 (22 female and 48 male) formed the control group. Gensini scoring system (GSS) was significantly higher in the ARG than in the control group (80.5 (36-166) vs. 45 (2-209); p<0.001). The number of percutaneous coronary intervention (PCI) patients was significantly higher in the ARG (13 of 30 (43.3%) ARG vs. 13 of 70 (18.6%) control group; p=0.01). Furthermore, when we evaluate the 16 reintervention patients, stent restenosis was significantly higher in the ARG (11 of 16 (68.75%) ARG vs. 5 of 16 (31.25%) control group; p=0.016). Multivariate logistic regression analysis revealed that GSS (p=0.038; 95% CI: 1.001-1.026) and PCI history (p=0.017; 95% CI: 1.182-89.804) were independent risk factors for aspirin resistance. CONCLUSION: In conclusion, atherosclerotic burden as calculated by the GSS is significantly higher in aspirin-resistant patients. According to this result, we suggest that aspirin treatment can be prescribed in higher doses in aspirin resistance patients with coronary events. Furthermore, GSS and PCI history could be independent predictors of aspirin resistance.
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Serkan Kahraman (2017) conducted an observational in Coronary artery disease (n=100). Aspirin resistance vs. Aspirin sensitivity (control group) was evaluated on Extent and severity of atherosclerosis assessed by the Gensini scoring system (GSS) (p=<0.001). Aspirin resistance was associated with a significantly higher atherosclerotic burden, with a median Gensini score of 80.5 compared to 45 in aspirin-sensitive patients.
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