Mechanistic assessment and ablation of left ventricular assist device related ventricular tachycardia in patients with severe heart failure
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Why the study?
Heart failure patients have significant substrate for VT and the LVAD itself may be pro-arrhythmogenic, prompting investigation into VT mechanisms in LVAD patients by underlying etiology and data for ablation.
What is the mechanism of ventricular tachycardia in LVAD patients, and what are the outcomes of radiofrequency ablation?
Population
17 patients with VT and LVAD
Comparison
VT originating from the LVAD region vs other regions
Design
Retrospective study with in silico and ex-vivo experiments
Authors
Discussion
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Implication
May guide ablation targets near LVAD in VT; leaves open efficacy pending prospective validation.
Structured PICO
What is the mechanism of ventricular tachycardia in LVAD patients, and what are the outcomes of radiofrequency ablation?
P
Population
17 patients with severe heart failure with reduced ejection fraction (HFrEF) and a left ventricular assist device (LVAD) presenting with ventricular tachycardia (VT). 70% had ischemic cardiomyopathy.
I
Intervention
Radiofrequency (RF) ablation of ventricular tachycardia, supplemented by in silico and ex-vivo experiments targeting ventricular myocardium
O
Outcome
Mechanism and origin of ventricular tachycardia, and long-term freedom from VT upon ablationhard clinical
Cite This Study
Hohendanner et al. (2023) studied this question.
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