Characterization of ventricular tachycardia ablation in end-stage heart failure patients with left ventricular assist device (CHANNELED registry)
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Key result
Ventricular tachycardia ablation in patients with a left ventricular assist device achieved acute non-inducibility in 39% of procedures, with a 55% rate of VT recurrence during follow-up.
Why the study?
Patients with LVADs are at high risk for ventricular tachycardia, but data on VT ablation in this population are scarce.
Population
69 patients with LVAD undergoing 72 ablation procedures across nine tertiary care centres
Design
Retrospective multicentre registry
Follow-up
Median 283 days
Authors
Discussion
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Implication
Multicentre registry supports VT ablation feasibility in LVAD patients; leaves open questions on long-term efficacy and optimal patient selection.
Study Design
Type
Cohort (n=69)
Multicenter
Yes
Structured PICO
P
Population
69 predominantly male patients (mean age 60.7 years) with end-stage heart failure and a left ventricular assist device who underwent ventricular tachycardia ablation, followed for a median of 283 days.
E
Exposure
Ventricular tachycardia (VT) ablation
O
Outcome
VT mechanisms, procedural parameters, VT recurrence, and mortalityhard clinical
VT ablation in patients with LVADs is feasible and safe, but is associated with high VT recurrence and limited overall prognosis due to extensive cardiomyopathy-associated scar burden.
Limitations
- Non-randomized retrospective registry design
- Heterogeneity in procedural approaches, mapping, and ablation strategies across centers
- Small overall sample size precluding advanced statistical analysis
Cite This Study
Bruck et al. (2025) conducted a cohort in End-stage heart failure with left ventricular assist device and ventricular tachycardia (n=69). Ventricular tachycardia ablation was evaluated on Non-inducibility of any ventricular tachycardia at the end of the procedure. Ventricular tachycardia ablation in patients with a left ventricular assist device achieved acute non-inducibility in 39% of procedures, with a 55% rate of VT recurrence during follow-up.
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