Sildenafil Prevents Endothelial Dysfunction Induced by Ischemia and Reperfusion via Opening of Adenosine Triphosphate–Sensitive Potassium Channels
Why the study?
Does oral sildenafil prevent endothelial dysfunction induced by ischemia-reperfusion in healthy male volunteers?
Population
17 healthy male volunteers across two protocols.
Comparison
Oral sildenafil 50 mg administered 2 hours… vs Matching placebo administered 2 hours before…
Design
RCT, Randomized (crossover design), Double-blind
Follow-up
2 hours post-dose
Authors
Discussion
Loading...
Member takes
Implication
Supports testing sildenafil for cardioprotection in at-risk patients; extends prior observations to a human ischemia-reperfusion model.
Structured PICO
Does oral sildenafil prevent endothelial dysfunction induced by ischemia-reperfusion in healthy male volunteers?
P
Population
17 healthy male volunteers (25 to 45 years old) across two protocols (10 in the main crossover protocol, 7 in a separate mechanistic protocol).
I
Intervention
Oral sildenafil 50 mg administered 2 hours before ischemia-reperfusion (15 minutes of ischemia at the level of the brachial artery followed by 15 minutes of reperfusion).
C
Comparator
Matching placebo administered 2 hours before ischemia-reperfusion.
O
Outcome
Endothelium-dependent, flow-mediated dilatation (FMD) of the radial artery measured before and after ischemia-reperfusion.surrogate
Oral sildenafil provides potent protection against ischemia-reperfusion-induced endothelial dysfunction in humans, an effect mediated by the opening of K(ATP) channels.
Cite This Study
Gori et al. (2005) studied this question.