Why the study?
Does sildenafil reduce infarct size in isolated rat hearts undergoing ischemia-reperfusion?
Population
Male Wistar rats, isolated hearts mounted on a Langendorff system undergoing 30 min of global ischemia…
Comparison
Sildenafil administered over 10 min before the… vs Control group receiving no further treatment…
Design
Preclinical, randomized
Follow-up
60 min of reperfusion
Authors
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Supports sildenafil cardioprotection via PKG-BKCa in rat hearts; hypothesis-generating and should not yet change practice.
Does sildenafil reduce infarct size in isolated rat hearts undergoing ischemia-reperfusion?
Sildenafil-induced cardioprotection against ischemia-reperfusion injury in rat hearts is mediated by protein kinase G-dependent opening of mitochondrial BKCa channels.
Behmenburg et al. (2015) studied this question.
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