Why the study?
Does sildenafil prolong cardiac repolarization and block I(Kr) in isolated hearts and transfected cells?
Population
10 isolated guinea pig hearts, human ether-a-go-go-related gene-transfected HEK293 cells, and…
Comparison
Sildenafil vs Baseline (before sildenafil administration)
Design
Preclinical
Authors
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May warrant arrhythmia caution in at-risk patients; leaves open clinical translation pending human studies.
Does sildenafil prolong cardiac repolarization and block I(Kr) in isolated hearts and transfected cells?
Sildenafil demonstrates direct cardiac electrophysiological effects similar to class III antiarrhythmic drugs by blocking the rapid component of the delayed rectifier potassium current, potentially explaining sudden death in predisposed patients.
Geelen et al. (2000) studied this question.
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