Why the study?
Does sildenafil reduce ischaemia-induced ventricular arrhythmias in a canine model of coronary occlusion?
Population
Mongrel dogs subjected to a 25 min occlusion of the anterior descending coronary artery
Comparison
Sildenafil 2 mg/kg oral given 24 hours prior to… vs Control group (treatment not specified)
Design
Preclinical
Follow-up
24 hours plus 25 minutes of occlusion
Authors
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No immediate clinical implications; leaves open translation of anti-arrhythmic effects from canine ischaemia to patients.
Does sildenafil reduce ischaemia-induced ventricular arrhythmias in a canine model of coronary occlusion?
Oral sildenafil administered 24 hours prior to coronary occlusion reduces the severity of ischaemia-induced ventricular arrhythmias in a canine model.
Nagy et al. (2004) studied this question.
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