August 1, 2002Cardiovascular ResearchOpen Access

Effects of sildenafil on cardiac repolarization

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Why the study?

Does sildenafil affect cardiac repolarization in preclinical animal models?

Population

Isolated guinea pig papillary muscles, canine Purkinje fibers, guinea pig ventricular myocytes, and intact…

Comparison

Sildenafil vs Control/baseline, D-sotalol, and amiodarone

Design

Preclinical

Authors

CCChern‐En ChiangCross-Cutting Cardiology

Discussion

Member takes

Implication

Sildenafil appears neutral on repolarization in animal models; leaves open translation to human QT safety or drug interactions.

Structured PICO

Does sildenafil affect cardiac repolarization in preclinical animal models?

Population

Isolated guinea pig papillary muscles, canine Purkinje fibers, guinea pig ventricular myocytes, and intact guinea pigs

Intervention

Sildenafil (in vitro concentrations up to 30 microM; in vivo 10 and 30 mg/kg orally)

Comparator

Control/baseline, D-sotalol, and amiodarone

Outcome

Cardiac repolarization parameters including Action potential duration at 90% repolarization (APD90), delayed rectifier potassium currents, L-type Ca2+ current, and QTc intervalsurrogate

Sildenafil does not prolong cardiac repolarization and may actually accelerate it at supra-therapeutic concentrations by blocking L-type calcium currents, suggesting it is not inherently proarrhythmic via QT prolongation.

Cite This Study

Chern‐En Chiang (2002) studied this question.

synapsesocial.com/papers/6a813e62ec86ba91653bfc46 https://doi.org/10.1016/s0008-6363(02)00438-8

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Effects of sildenafil on cardiac repolarization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of sildenafil on cardiac repolarization

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider