What question did this study set out to answer?

To evaluate the relationship between insulin sensitivity, insulin resistance, and central aortic blood pressure compared to traditional brachial cuff measurements.

October 1, 2011Journal of Hypertension

Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance

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Why the study?

Is impaired insulin sensitivity and resistance associated with differences between brachial and central systolic blood pressure in a healthy general population?

Population

1034 Japanese participants (healthy general population)

Design

Cross-sectional

Authors

YTYasuharu TabaraPreventive Cardiology ISIsao SaitoOita University WNWataru NishidaEhime University

Discussion

Member takes

Implication

Insulin resistance links to brachial-central SBP differences; leaves open whether central BP refines risk assessment in this population.

Key Points

To evaluate the relationship between insulin sensitivity, insulin resistance, and central aortic blood pressure compared to traditional brachial cuff measurements.
Enrolled 1034 Japanese participants who underwent a 75 g oral glucose tolerance test with blood sampling at 0, 60, and 120 minutes.
Estimated central systolic blood pressure (SBP2) using the late systolic peak of radial pulse waveforms and compared it with standard brachial systolic blood pressure (SBP).
Mean central SBP2 was significantly lower than mean brachial SBP (119 ± 20 mmHg vs. 126 ± 19 mmHg, P < 0.001).
The difference between brachial SBP and central SBP2 widened across quartiles of decreasing insulin sensitivity (-8.2 ± 5.2 to -6.5 ± 4.9 mmHg, P = 0.002) and increasing insulin resistance (-6.6 ± 5.1 to -8.5 ± 5.6 mmHg, P < 0.001).
Multiple linear regression confirmed reduced insulin sensitivity (β = 0.067, P = 0.033) and increased insulin resistance (β = -0.081, P = 0.009) as independent determinants of the SBP-SBP2 discrepancy.

Structured PICO

Is impaired insulin sensitivity and resistance associated with differences between brachial and central systolic blood pressure in a healthy general population?

Population

1034 Japanese participants (healthy general population)

Intervention

Assessment of insulin sensitivity and resistance using a 75 g oral glucose tolerance test

Outcome

Difference between brachial systolic blood pressure (SBP) and central systolic blood pressure (SBP2)surrogate

Impaired insulin sensitivity and resistance are associated with a larger difference between brachial and central systolic blood pressure, suggesting central BP measurement may be more accurate for cardiovascular risk assessment in these individuals.

Cite This Study

Tabara et al. (2011) studied this question.

synapsesocial.com/papers/6a729c58660549caf2c6b8ea https://doi.org/10.1097/hjh.0b013e32834abd06

Topics

Hypertension management Women and heart disease

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Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relatively lower central aortic pressure in patients with impaired insulin sensitivity and resistance

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider