Population
Cardiac fibroblasts from the left ventricle of spontaneously hypertensive and normotensive Wistar-Kyoto rats
Comparison
Stimulation with angiotensin II, bradykinin, or… vs Nonstimulated conditions and comparison between…
Design
Preclinical
Authors
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These animal findings should not alter clinical hypertension management; leaves open prostacyclin roles in human cardiac fibrosis.
Phenotypic differences in prostacyclin production and responsiveness between SHR and WKY cardiac fibroblasts suggest that the SHR genetic hypertension model may be predisposed to excess cardiac fibrosis.
Yu et al. (1997) studied this question.
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