Why the study?
Does inosine reduce the size of myocardial ischaemia in a pig model of acute coronary occlusion?
Population
Open chest pigs undergoing 15 min occlusions of the left anterior descending coronary artery followed by 45…
Comparison
Inosine administered i.v. throughout the… vs 0.9% NaCl infusion administered i.v. throughout…
Design
Preclinical
Follow-up
15 min occlusion followed by 45 min reperfusion
Authors
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Hypothesis-generating for inosine in acute ischaemia; leaves open translation to clinical cardioprotection.
Does inosine reduce the size of myocardial ischaemia in a pig model of acute coronary occlusion?
Inosine decreases the area of ischaemic injury induced by acute coronary occlusion in a preclinical pig model.
Czarnecki et al. (1982) studied this question.
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