November 1, 1981Cardiovascular Research

Inosine as a selective inotropic agent on ischaemic myocardium?

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Why the study?

Does intravenous inosine selectively improve regional myocardial performance in an open-chested pig model of coronary occlusion?

Population

Open-chested pig model with coronary occlusion

Comparison

Intravenous infusion of inosine (15 mg.kg-1.min-1) vs Glucose-insulin-potassium

Design

Preclinical

Authors

KWKeith V WoollardMurdoch University RKR. O KINGABYCharing Cross Hospital MLM J LabUniversity of London

Discussion

Member takes

Implication

Does not support clinical use; leaves open translation of selective inotropy to human ischemia.

Structured PICO

Does intravenous inosine selectively improve regional myocardial performance in an open-chested pig model of coronary occlusion?

Population

Open-chested pig model with coronary occlusion

Intervention

Intravenous infusion of inosine (15 mg.kg-1.min-1)

Comparator

Glucose-insulin-potassium

Outcome

Regional myocardial performance of ischaemic myocardium relative to nonischaemic myocardiumsurrogate

Inosine demonstrates selective inotropic effects on ischemic myocardium in a porcine model, driven by multifactorial mechanisms including vasodilatory and metabolic actions.

Cite This Study

Woollard et al. (1981) studied this question.

synapsesocial.com/papers/6a89b0ac44eed047faeb1cd7 https://doi.org/10.1093/cvr/15.11.659

View Full Paper

Ask AI

Bookmark

Inosine as a selective inotropic agent on ischaemic myocardium?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inosine as a selective inotropic agent on ischaemic myocardium?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider