Why the study?
Does intravenous inosine alter myocardial substrate uptake and cardiac function in anaesthetized dogs?
Population
8 closed-chest pentobarbital anaesthetized dogs
Design
Preclinical
Authors
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Inosine effects in dogs are hypothesis-generating; should not influence clinical practice without human data.
Does intravenous inosine alter myocardial substrate uptake and cardiac function in anaesthetized dogs?
Inosine infusion in dogs shifts myocardial metabolism towards carbohydrate uptake and exerts positive inotropic and vasodilatory effects, associated with insulin release.
Smiseth et al. (1989) studied this question.
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