January 1, 1981Japanese Heart JournalOpen Access

Effect of Inosie on left ventricular performance and its clinical significance.

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Why the study?

Does intravenous inosine improve left ventricular hemodynamic performance in patients with various cardiac diseases?

Population

16 hospitalized patients with various cardiac diseases and normal hearts, NYHA class I to III.

Design

Case_series

Follow-up

15 minutes

Authors

YYYoshimasa YabeJikei University School of Medicine SYShozo YoshimuraTokyo Institute of Technology

Discussion

Member takes

Implication

Inosine may improve LV hemodynamics in cardiac disease; case-report data leave its role hypothesis-generating pending controlled trials.

Structured PICO

Does intravenous inosine improve left ventricular hemodynamic performance in patients with various cardiac diseases?

Population

16 hospitalized patients (mean age 47, 13 males) with various cardiac diseases (effort angina pectoris n=2, myocardial infarction n=4, valvular disease n=3, idiopathic cardiomyopathy n=2, congenital heart disease n=3) and normal hearts (n=2), NYHA class I to III.

Intervention

Inosine 200 mg diluted in 30 ml saline administered intravenously via central vein over 3 minutes.

Outcome

Time-course of various hemodynamic parameters (pulmonary wedge pressure, heart rate, LVP, LVEDP, max dp/dt, dp/dt/P, and cardiac output) including ejection fraction up to 15 minutes post-injection.surrogate

Intravenous inosine exerts a favorable influence on left ventricular function through a remarkable load-reducing effect and positive inotropic effect, particularly in patients with disturbed cardiac function.

Limitations

Differences in the specificity and reproducibility of each parameter of the cardiac function used
Difficulties in the method for obtaining further parameters

Cite This Study

Yabe et al. (1981) studied this question.

synapsesocial.com/papers/6a72229475498292b70b5b59 https://doi.org/10.1536/ihj.22.915

Topics

Congenital heart disease adults Hypertrophic cardiomyopathy Valvular heart disease

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Effect of Inosie on left ventricular performance and its clinical significance.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Effect of Inosie on left ventricular performance and its clinical significance.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider