This preclinical study found no evidence of a peripherally acting pathogenetic pressor substance in the blood of renal hypertensive dogs, though it does not definitively rule out its existence.
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Does not support circulating pressor factor in canine renal hypertension; leaves open alternative mechanisms for further study.
The effects of citrated blood plasmas from 6 normal and 6 renal hypertensive dogs on the tonus of arterial segments from the mesenteric arteries of beeves were studied. 2. No significant differences were found in the vasoconstricting properties of the normal and hypertensive plasmas. 3. These results speak against the presence of a peripherally acting pathogenetic pressor substance in the blood of Goldblatt dogs but by no means rule out this possibility.
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Wakerlin et al. (1939) studied this question.
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