Gene Polymorphisms and Variability of Human Apolipoproteins

Q: What is the clinical evidence from this study?

Study design: Review. Population: Human apolipoprotein gene polymorphisms and lipid transport. Intervention: Apolipoprotein gene polymorphisms.

Q: What does this research mean for the field?

Genetic polymorphisms and structural variability across human apolipoprotein genes directly influence individual variability in lipid transport and lipoprotein metabolism. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Edward A. Fisher; Paul M. Coates; J A Cortner

doi:10.1146/annurev.nu.09.070189.001035

July 1, 1989Annual Review of Nutrition

Gene Polymorphisms and Variability of Human Apolipoproteins

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Key result

Apolipoprotein gene cluster polymorphisms shape human lipid transport and variability.

Key Points

To review the chromosomal localization, evolutionary background, and polymorphic variability among major human apolipoprotein genes regulating lipid metabolism.
Narrative review detailing molecular genetics and known polymorphic sites across apolipoprotein gene families.
Evaluation of genomic structures including the APOA1/APOC3/APOA4 gene cluster, APOB, APOC2, APOE, and LPA loci.
Categorizes natural genetic variations across key apolipoproteins governing exogenous, endogenous, and reverse cholesterol transport pathways.
Synthesizes structural organization and polymorphic markers across the APOA, APOB, APOC, APOD, and APOE gene families.

PICO

P

Population

Human apolipoprotein gene polymorphisms and lipid transport

I

Intervention / Comparator

Apolipoprotein gene polymorphisms

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Answers are grounded in this paper and cite their sources.

Implication

Review outlines genetic variations across human apolipoprotein loci, highlighting their regulatory roles in dietary and endogenous lipid transport.

Abstract

INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 40 Transport of Exogenous (Dietary) Li pids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 40 Transport of Endogenous Lipids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 1 HDL and Reverse Cholesterol Transport . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 4 1 APOLIPOPROTEIN GENES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 42 Chromosomal Localization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 42 Evolutionary Considerations .. . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 42 APOLIPOPROTEIN GENE VARIATION . . . . . . . . .. . . .. . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . 1 45 Meth ods to Study Varia bility of Apolipoprotein Genes... . . . . . . . . . . . . 1 45 ApoA-/IC-III1A-/V Gene Cluster. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 46 ApoA-1I Gene . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 48 ApoB Gene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 49 ApoC-lI Gene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 52 ApoE Gene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 53 Apo(a ) Gene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 ApoD Gene. . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 CONCLUDING REMARKS . . . . . . . . . . . . . . . .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 55

Discussion

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Cite This Study

Fisher et al. (1989) conducted a review in Human apolipoprotein gene polymorphisms and lipid transport. Apolipoprotein gene polymorphisms was evaluated. Human apolipoprotein gene polymorphisms and variability across major gene clusters (ApoA, ApoB, ApoC, ApoD, ApoE, Apo(a)) are reviewed regarding lipid transport.

synapsesocial.com/papers/6a72b54435aa2c282ce3642c https://doi.org/10.1146/annurev.nu.09.070189.001035

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Gene Polymorphisms and Variability of Human Apolipoproteins

Key Points

PICO

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Implication

Abstract

Discussion

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Gene Polymorphisms and Variability of Human Apolipoproteins

Key Points

PICO

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Implication

Abstract

Discussion

Cite This Study

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