Why the study?
Does verapamil reduce myocardial inflammation and necrosis in a murine model of viral myocarditis?
Population
117 8-wk-old DBA/2 mice
Comparison
Verapamil given either as pretreatment or… vs Infected controls receiving no verapamil, and…
Design
Preclinical, randomized to three treatment regimens, Routine histology was…
Follow-up
28 days
Authors
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Reduces myocardial damage in murine viral myocarditis; leaves open translation to human disease.
Does verapamil reduce myocardial inflammation and necrosis in a murine model of viral myocarditis?
Verapamil significantly reduces microvascular changes and myocardial necrosis in a murine model of viral myocarditis, suggesting a role for calcium and microvascular spasm in pathogenesis.
Dong et al. (1992) studied this question.
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