Why the study?
Does enhanced vascular renin-angiotensin activity cause vascular hypertrophy in excess of pressure elevation alone in hypertensive rats?
Population
Transgenic27 rats, spontaneously hypertensive rats, and their respective normotensive control rats
Comparison
Transgenic expression of mRen-2 vs Spontaneously hypertensive rats and normotensive…
Design
Preclinical
Authors
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Animal data suggest renin-angiotensin drives hypertrophy beyond pressure; leaves open human translation and clinical relevance.
Does enhanced vascular renin-angiotensin activity cause vascular hypertrophy in excess of pressure elevation alone in hypertensive rats?
Enhanced vascular renin-angiotensin activity causes vascular hypertrophy in excess of the hypertrophy associated with pressure elevation alone, leading to reduced arterial wall stress.
Struijker-Boudier et al. (1996) studied this question.
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