Key result
Transgenic rats with low-renin hypertension exhibited increased active effective pressure, decreased lumen diameter, and increased media thickness without cellular hypertrophy or hyperplasia.
Population
13-week-old transgenic rats with low-renin hypertension and age-matched Sprague-Dawley controls
Comparison
Transgenic expression of mouse Ren-2 renin gene vs Age-matched Sprague-Dawley controls
Design
Preclinical
Authors
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May inform vascular properties in low-renin hypertension models; leaves open human translation.
In a transgenic rat model of low-renin hypertension, increased pressure response is mediated by structural rearrangement of existing vascular material rather than cellular hypertrophy or hyperplasia.
Thybo et al. (1992) studied Low-renin hypertension. Transgenic mouse Ren-2 renin gene vs. Age-matched Sprague-Dawley controls was evaluated on Pharmacological and morphological properties of mesenteric resistance arteries. Transgenic rats with low-renin hypertension exhibited increased active effective pressure, decreased lumen diameter, and increased media thickness without cellular hypertrophy or hyperplasia.
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