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June 1, 1978Clinical Pharmacology & Therapeutics

Gastrointestinal blood loss after diflunisal and after aspirin: Effect of ethanol

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Why the study?

Does diflunisal cause less gastrointestinal blood loss compared to aspirin, and how does alcohol affect this?

Population

12 normal subjects (10 in a parallel study, 2 in a crossover study)

Comparison

Diflunisal 250 mg twice daily vs Acetylsalicylic acid 750 mg or 600 mg 4 times…

Design

RCT, double-blind

Follow-up

4-day treatment period

Authors

PDPablo DeschepperTTT. B. TjandramagaMRM. De Roo

Discussion

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Overview

Diflunisal may be preferred over ASA to minimize GI blood loss, especially with alcohol; confirms differential NSAID effects in RCT data.

Structured PICO

Does diflunisal cause less gastrointestinal blood loss compared to aspirin, and how does alcohol affect this?

P
Population
12 normal subjects (10 in a parallel study, 2 in a crossover study)
I
Intervention
Diflunisal 250 mg twice daily (with or without alcohol)
C
Comparator
Acetylsalicylic acid (ASA) 750 mg or 600 mg 4 times daily (with or without alcohol)
O
Outcome
Fecal blood loss evaluated with 51Cr-labeled red cellssafety

Diflunisal causes less gastrointestinal blood loss than aspirin, and unlike aspirin, its effect is not significantly enhanced by alcohol.

Cite This Study

Deschepper et al. (1978) studied this question.

synapsesocial.com/papers/6a72bc6aabc331a85807c103https://doi.org/10.1002/cpt1978236669
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diflunisal versus aspirin: a comparative study of their effect on faecal blood loss, in the presence and absence of alcohol1978 · 9 citations
  2. 2Effects of Diflunisal on Platelet Function and Fecal Blood Loss1983 · 5 citations
  3. 3Effects of diflunisal on platelet function and fecal blood loss1981 · 30 citations
  4. 4Effect of diflunisal on platelet function and blood coagulation.1977 · 28 citations
  5. 5Comparison of Fecal Blood Loss after Use of Aspirin and Suprofen2008 · 8 citations