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March 1, 1983Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Effects of Diflunisal on Platelet Function and Fecal Blood Loss

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Why the study?

Does diflunisal inhibit platelet function and increase fecal blood loss less than aspirin in normal subjects?

Population

Normal subjects

Comparison

Diflunisal 250, 500, or 1,000 mg twice daily for… vs Aspirin 650 or 1,300 mg twice daily, or placebo…

Design

RCT, randomized, double-blind

Follow-up

8-day periods

Authors

DGDavid GreenRDRichard O. DaviesGHGeoffrey I. Holmes

Discussion

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Overview

Diflunisal may be preferable to aspirin when minimizing platelet inhibition or GI blood loss; confirms lesser effects in this RCT.

Structured PICO

Does diflunisal inhibit platelet function and increase fecal blood loss less than aspirin in normal subjects?

P
Population
Normal subjects
I
Intervention
Diflunisal 250, 500, or 1,000 mg twice daily for 8-day periods
C
Comparator
Aspirin 650 or 1,300 mg twice daily, or placebo for 8-day periods
O
Outcome
Platelet function (collagen-induced platelet aggregation, serotonin release, malondialdehyde production), template bleeding times, and fecal blood losssurrogate

Diflunisal inhibits platelet function and increases fecal blood loss to a lesser extent and for a shorter duration than comparable doses of aspirin.

Cite This Study

Green et al. (1983) studied this question.

synapsesocial.com/papers/6a72bcd2abc331a85807c111https://doi.org/10.1002/phar.1983.3.2p2.65
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of platelet prostaglandin synthetase by oral aspirin.1978 · 558 citations
  2. 2A Study of the Variable Response of Human Platelets to Collagen: Relation to Aspirin-induced Inhibition of Aggregation1973 · 32 citations
  3. 3Inhibition of Primary ADP-Induced Platelet Aggregation in Normal Subjects after Administration of Nitrofurantoin (Furadantin)1973 · 25 citations
  4. 4Incidence of Gastric Lesions in Patients with Rheumatic Disease on Chronic Aspirin Therapy1979 · 318 citations
  5. 5Aspirin Use in Patients with Major Upper Gastrointestinal Bleeding and Peptic-Ulcer Disease1974 · 306 citations