Why the study?
Does diflunisal affect platelet aggregation and clinical bleeding in patients with pain and normal subjects?
Population
15 patients with musculo-skeletal pain and other painful conditions, and 5 normal subjects (total n=20)
Comparison
Diflunisal 250 mg twice or 3-times daily vs Baseline (before treatment)
Design
Cohort
Authors
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Diflunisal may be platelet-sparing in this cohort; should not yet change practice and leaves open need for RCTs.
Does diflunisal affect platelet aggregation and clinical bleeding in patients with pain and normal subjects?
Diflunisal at 250 mg twice or three times daily does not significantly impair platelet function or cause clinical bleeding.
Ghosh et al. (1980) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: