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February 1, 1977British Journal of Clinical PharmacologyOpen Access

Effect of diflunisal on platelet function and blood coagulation.

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Why the study?

Does diflunisal affect platelet function and blood coagulation in healthy male volunteers?

Population

26 healthy males (20 in double-blind trial, 6 in open-label high-dose study)

Comparison

Diflunisal vs Placebo (for the double-blind group)

Design

RCT, Randomly assigned, Double-blind for the main group; open design for the…

Follow-up

Up to 33 days

Authors

CSC.T. Smit SibingaDialyse Centrum Groningen

Discussion

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Overview

Supports diflunisal without coagulation monitoring at analgesic doses; confirms minimal platelet effects in healthy volunteers.

Structured PICO

Does diflunisal affect platelet function and blood coagulation in healthy male volunteers?

P
Population
26 healthy males (20 in double-blind trial, 6 in open-label high-dose study)
I
Intervention
Diflunisal (acute single oral dose on day 1, followed by chronic multiple dose twice daily orally from day 15 to day 21)
C
Comparator
Placebo (for the double-blind group)
O
Outcome
Platelet function and blood coagulation parameters (haemoglobin, mH, blood glucose, platelet counts, bleeding time, ADP- and collagen-induced platelet aggregation, PT, PTT, thrombin time, fibrinogen, antithrombin III, clot lysis, serum FDP)surrogate

Diflunisal does not significantly impair platelet function or blood coagulation at standard analgesic doses in healthy volunteers.

Cite This Study

C.T. Smit Sibinga (1977) studied this question.

synapsesocial.com/papers/6a72bc6aabc331a85807c104https://doi.org/10.1111/j.1365-2125.1977.tb04512.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of diflunisal on platelet function and fecal blood loss1981 · 30 citations
  2. 2Effects of Diflunisal on Platelet Function and Fecal Blood Loss1983 · 5 citations
  3. 3Platelet aggregation in patients treated with diflunisal1980 · 4 citations
  4. 4Effect of dose on the glucuronidation and sulphation kinetics of diflunisal in man: single dose studies.1988 · 32 citations
  5. 5Diflunisal versus aspirin: a comparative study of their effect on faecal blood loss, in the presence and absence of alcohol1978 · 9 citations