Why the study?
Does TCV-116 or delapril attenuate left ventricular dilatation and haemodynamic alterations after myocardial infarction in hypertensive and normotensive rats?
Population
Spontaneously hypertensive rats and normotensive rats with myocardial infarction produced by coronary artery…
Comparison
TCV-116 or delapril for three weeks vs Untreated controls
Design
Preclinical
Follow-up
three weeks
Authors
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Supports preclinical post-MI remodeling studies in hypertension; leaves open translation to human therapy.
Does TCV-116 or delapril attenuate left ventricular dilatation and haemodynamic alterations after myocardial infarction in hypertensive and normotensive rats?
Angiotensin II type 1 receptor antagonists and ACE inhibitors attenuate left ventricular dilatation and adverse hemodynamic alterations following myocardial infarction in both hypertensive and normotensive rat models.
Nishikimi et al. (1995) studied this question.
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