What question did this study set out to answer?

To determine the biochemical alterations and left ventricular functional changes associated with antihypertensive-induced reversal of left ventricular hypertrophy in spontaneously hypertensive rats.

September 1, 1993Journal of Hypertension

Biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does amlodipine, benazepril, or their combination improve biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, aged 19 weeks

Comparison

Amlodipine, benazepril, or combination for 3 weeks vs Vehicle

Design

Preclinical

Follow-up

3 weeks

Authors

MAMikio AritaYamaguchi University SHShigeo HorinakaDokkyo Medical University EFEdward D. FröhlichGeneral Cardiology

Discussion

Member takes

Implication

Does not support immediate practice changes; leaves open translation of combination benefits in hypertensive rat models to clinical LVH reversal.

Key Points

To determine the biochemical alterations and left ventricular functional changes associated with antihypertensive-induced reversal of left ventricular hypertrophy in spontaneously hypertensive rats.
Male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats aged 19 weeks received 3 weeks of vehicle, amlodipine (10 mg/kg), benazepril (10 mg/kg), or combination therapy (4 mg/kg each).
Left ventricular performance was measured during rapid blood infusion at pharmacologically reduced and pretreatment mean arterial pressure, alongside myocardial assays for protein, RNA, DNA, and collagen.
All active treatments significantly reduced mean arterial pressure and left ventricular mass in SHR, showing proportional reductions in myocardial protein, RNA, and collagen while DNA remained unchanged.
Amlodipine increased right ventricular mass in both SHR (+11.3%) and WKY rats (+9.8%), accompanied by increased right ventricular protein and collagen in SHR, which was prevented by benazepril coadministration.
Under acute pressure elevation back to pretreatment levels, neither single agent altered left ventricular pumping ability in SHR, whereas combination therapy significantly enhanced it.

Structured PICO

Does amlodipine, benazepril, or their combination improve biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats?

Population

Male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats, aged 19 weeks

Intervention

Amlodipine (10 mg/kg), benazepril (10 mg/kg), or combination (4 mg/kg amlodipine and 4 mg/kg benazepril) for 3 weeks

Comparator

Vehicle

Outcome

Biochemical and left ventricular functional changes (mean arterial pressure, left ventricular mass, myocardial protein, RNA, collagen, DNA, right ventricular mass, and left ventricular pumping ability)surrogate

Amlodipine, benazepril, and their combination reverse left ventricular hypertrophy in spontaneously hypertensive rats without increasing fibrous tissue or impairing left ventricular performance, while combination therapy prevents amlodipine-induced right ventricular mass increase.

Cite This Study

Arita et al. (1993) studied this question.

synapsesocial.com/papers/6a71715bac440176ef2a248f https://doi.org/10.1097/00004872-199309000-00009

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Implication

Does not support immediate practice changes; leaves open translation of combination benefits in hypertensive rat models to clinical LVH reversal.

Biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Biochemical components and myocardial performance after reversal of left ventricular hypertrophy in spontaneously hypertensive rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider