Why the study?
Do angiotensin II receptor antagonists provide similar clinical benefits to ACE inhibitors without the adverse effect of cough in patients with chronic heart failure?
Do angiotensin II receptor antagonists provide similar clinical benefits to ACE inhibitors without the adverse effect of cough in patients with chronic heart failure?
This article discusses the theoretical rationale for using angiotensin II receptor antagonists instead of ACE inhibitors in heart failure to avoid bradykinin-induced cough.
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Supports theoretical preference for ARBs in ACEI-intolerant HF; leaves open confirmation of equivalent outcomes.
Allan D. Struthers (1998) studied this question.