The prognostic impact of coronary anatomy in myocardial infarction with nonobstructive coronary artery disease: a seven-year longitudinal follow-up
Why the study?
The prognostic impact of nonobstructive coronary artery anatomy on long-term outcomes in patients with MINOCA remains unclear.
Does nonobstructive coronary artery anatomy compared to normal coronary anatomy increase the risk of major adverse events in patients with MINOCA?
Population
1,544 consecutive MINOCA patients at a large referral medical center in Israel
Comparison
NOCAA vs NCAA
Design
Retrospective cohort study
Follow-up
Median 7 years
Authors
Discussion
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Member takes
Implication
NOCAA may identify higher-risk MINOCA patients; leaves open need for prospective validation before changing practice.
Structured PICO
Does nonobstructive coronary artery anatomy compared to normal coronary anatomy increase the risk of major adverse events in patients with MINOCA?
P
Population
1,544 patients with myocardial infarction with nonobstructive coronary arteries (MINOCA), mean age 61.2±12.6 years, 46.0% female, from a large referral medical center in Israel between 2005-2018. Excluded patients with probable alternative causes for myocardial injury (stress-induced cardiomyopathy, myocarditis).
I
Intervention
Nonobstructive coronary artery anatomy (NOCAA)
C
Comparator
Normal coronary artery anatomy (NCAA)
O
Outcome
Major adverse events (MAE), defined as the composite of all-cause mortality and recurrent acute coronary syndrome (ACS)composite
In patients with MINOCA, the presence of nonobstructive coronary artery disease is associated with a significantly higher risk of long-term major adverse events compared to those with completely normal coronary arteries.
Cite This Study
Tsaban et al. (2022) studied this question.