Why the study?
Does central inhibition of angiotensin II mechanisms with teprotide or sarthran reduce blood pressure in spontaneously hypertensive rats?
Population
Male spontaneously hypertensive rats (SHR) weighing 240-300 g
Comparison
Chronic intraventricular infusion of converting… vs Baseline blood pressure / pre-infusion state
Design
Preclinical
Follow-up
Up to 3 weeks
Authors
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Central Ang II inhibition does not lower BP in adult SHR; leaves open its role in hypertension maintenance across models.
Does central inhibition of angiotensin II mechanisms with teprotide or sarthran reduce blood pressure in spontaneously hypertensive rats?
Central angiotensin II mechanisms do not appear to be the primary drivers for the maintenance of established hypertension in adult spontaneously hypertensive rats.
Bruner et al. (1987) studied this question.
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