Population
Cultured bovine aortic endothelial cells, isolated coronary arteries, and cultured rat aortic vascular…
Comparison
Conditioned medium from bovine aortic… vs Baseline or calcium channel antagonists
Design
Preclinical
Authors
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Hypothesis-generating for endothelial constrictors in vascular tone; leaves open clinical translation of calcium antagonists.
Endothelial cell-derived constrictors induce vascular smooth muscle contraction through a biphasic mechanism involving rapid intracellular calcium mobilization and sustained extracellular calcium influx.
Highsmith et al. (1989) studied this question.
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