Why the study?
Do ET-1 and ET-2 initiate and maintain contractile responses through different mechanisms in rat mesenteric and basilar arteries?
Population
Segments of rat mesenteric resistance artery (MRA) and basilar artery (BA)
Comparison
Endothelin-1 and Endothelin-2 with functional… vs Without functional antagonists
Design
Preclinical
Authors
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Mechanistic distinctions between ET-1/ET-2 in rat arteries leave open agonist- and bed-selective targeting; human relevance untested.
Do ET-1 and ET-2 initiate and maintain contractile responses through different mechanisms in rat mesenteric and basilar arteries?
ET-1 and ET-2 initiate and maintain vasoconstriction through distinct mechanisms that vary by vascular bed, suggesting potential for agonist- and vascular bed-selective pharmacotherapy.
Compeer et al. (2013) studied this question.
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