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October 7, 1978BMJOpen Access

Effect of quinidine on plasma concentration of digoxin.

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Why the study?

Do new contraceptive pill regimens (starting immediately or on the first day of the cycle) cause unacceptable menstrual problems in women?

Population

567 women starting or changing contraceptive pills

Design

Cohort

Authors

PHP. M. HooymansZuyderland Medisch CentrumFMF.W.H.M. MerkusLeiden University

Discussion

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Implication

Menstrual irregularities appear acceptable with immediate-start regimens; leaves open whether randomized trials would confirm broader safety and uptake.

Structured PICO

Do new contraceptive pill regimens (starting immediately or on the first day of the cycle) cause unacceptable menstrual problems in women?

P
Population
567 women starting or changing contraceptive pills
I
Intervention
New contraceptive pill regimens (starting new pill on 1st day of cycle or starting new pill immediately)
O
Outcome
Menstrual problems (spotting, breakthrough bleeding, amenorrhoea, heavy periods)patient reported

Starting or changing to low-dose contraceptive pills immediately or on the first day of the cycle is effective, acceptable to patients, and economical, with expected rates of menstrual irregularities.

Limitations

  • No control group

Cite This Study

Hooymans et al. (1978) studied this question.

synapsesocial.com/papers/6a72ce8722b3175134db7d49https://doi.org/10.1136/bmj.2.6143.1022-b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinically significant interaction between digoxin and quinidine.1979 · 16 citations
  2. 2Overall and bleeding-related discontinuation rates of a new oral contraceptive containing 4 mg drospirenone only in a 24/4 regimen and comparison to 0.075 mg desogestrel2021 · 16 citations
  3. 3Routine screening for coagulation inhibitors prior to prescribing the pill: prevalence data from a large cohort of German pill starters1996 · 6 citations
  4. 4Safety and Tolerability of Three Different Prolonged‐Release Dienogest/Ethinylestradiol Contraceptive Pills in an Extended 181‐Day Treatment Regimen Compared to a Flexible Immediate‐Release Formulation With Drospirenone/Ethinylestradiol2026
  5. 5Sexual behaviour among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: Data from the ECHO randomized trial2024 · 2 citations