December 1, 1979BMJOpen Access

Clinically significant interaction between digoxin and quinidine.

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Why the study?

Does the addition of quinidine to digoxin therapy increase plasma digoxin concentrations and cause toxicity?

Population

2 digitalised patients

Comparison

Addition of quinidine sulphate to maintenance… vs Baseline (digoxin therapy alone)

Design

Case_series

Authors

DHD W HoltSt George's, University of London AHA M HaylerNew Cross Hospital MEMichael EdmondsKing's College London

Discussion

Member takes

Implication

May signal digoxin-quinidine interaction risk; hypothesis-generating from case reports and requires prospective confirmation.

Structured PICO

Does the addition of quinidine to digoxin therapy increase plasma digoxin concentrations and cause toxicity?

Population

2 digitalised patients (a 69-year-old man with left ventricular failure and atrial flutter-fibrillation, and a 74-year-old woman with cor pulmonale and atrial tachycardia)

Intervention

Addition of quinidine sulphate (250 mg 8-hourly or 12-hourly) to maintenance digoxin therapy

Comparator

Baseline (digoxin therapy alone)

Outcome

Plasma digoxin concentration and clinical signs of digoxin toxicitysafety

The addition of quinidine to digoxin therapy can cause a clinically significant interaction leading to elevated plasma digoxin levels and toxicity, necessitating careful monitoring.

Cite This Study

Holt et al. (1979) studied this question.

synapsesocial.com/papers/6a9587df19dbadbb777cfc4b https://doi.org/10.1136/bmj.2.6202.1401

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December 1, 1979BMJOpen Access

Clinically significant interaction between digoxin and quinidine.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the addition of quinidine to digoxin therapy increase plasma digoxin concentrations and cause toxicity?

Population

2 digitalised patients

Comparison

Addition of quinidine sulphate to maintenance… vs Baseline (digoxin therapy alone)

Design

Case_series

Authors

DHD W HoltSt George's, University of London AHA M HaylerNew Cross Hospital MEMichael EdmondsKing's College London

Discussion

Member takes

Implication

May signal digoxin-quinidine interaction risk; hypothesis-generating from case reports and requires prospective confirmation.

Structured PICO

Does the addition of quinidine to digoxin therapy increase plasma digoxin concentrations and cause toxicity?

Population

2 digitalised patients (a 69-year-old man with left ventricular failure and atrial flutter-fibrillation, and a 74-year-old woman with cor pulmonale and atrial tachycardia)

Intervention

Addition of quinidine sulphate (250 mg 8-hourly or 12-hourly) to maintenance digoxin therapy

Comparator

Baseline (digoxin therapy alone)

Outcome

Plasma digoxin concentration and clinical signs of digoxin toxicitysafety

The addition of quinidine to digoxin therapy can cause a clinically significant interaction leading to elevated plasma digoxin levels and toxicity, necessitating careful monitoring.

Cite This Study

Holt et al. (1979) studied this question.

synapsesocial.com/papers/6a9587df19dbadbb777cfc4b https://doi.org/10.1136/bmj.2.6202.1401

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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