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February 4, 1978BMJOpen Access

Effect of quinidine on plasma concentrations of digoxin.

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Why the study?

Does quinidine increase plasma concentrations of digoxin in patients with atrial fibrillation or flutter?

Population

12 patients admitted for cardioversion of atrial fibrillation or flutter who had been receiving digoxin for…

Comparison

Quinidine sulphate followed by maintenance… vs Baseline plasma digoxin concentrations before…

Design

Case_series

Follow-up

3 to 5 days

Authors

GEG EjvinssonKarolinska University Hospital

Discussion

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Implication

May warrant digoxin monitoring with quinidine in AF; case reports leave open need for prospective confirmation.

Structured PICO

Does quinidine increase plasma concentrations of digoxin in patients with atrial fibrillation or flutter?

P
Population
12 patients admitted for cardioversion of atrial fibrillation or flutter who had been receiving digoxin for at least four weeks.
I
Intervention
Quinidine sulphate (loading dose 0.6-0.8 g depending on body weight) followed by maintenance quinidine bisulphate (250 mg tablets, 3 tablets twice daily) added to ongoing digoxin therapy.
C
Comparator
Baseline plasma digoxin concentrations before quinidine administration.
O
Outcome
Plasma concentrations of digoxin and quinidine.surrogate

Administration of quinidine to patients on maintenance digoxin therapy leads to a significant increase in plasma digoxin concentrations, increasing the risk of digitalis intoxication.

Cite This Study

G Ejvinsson (1978) studied this question.

synapsesocial.com/papers/6a95872ea15fb1352cb30104https://doi.org/10.1136/bmj.1.6108.279
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Quinidine Concentrations as a Guide in the Treatment of Cardiac Arrhythmias1950 · 109 citations
  2. 2Factors Influencing Conversion of Chronic Atrial Fibrillation with Special Reference to Serum Quinidine Concentration1956 · 112 citations
  3. 3Quantitative Determination of Quinidine in Plasma1963 · 175 citations
  4. 4THE ESTIMATION OF BASIC ORGANIC COMPOUNDS IN BIOLOGICAL MATERIAL1947 · 102 citations