Why the study?
Does 24-hour ambulatory blood pressure monitoring compared to casual clinic measurement reduce blood pressure variability and subsequent sample size requirements for clinical trials in the elderly?
Does 24-hour ambulatory blood pressure monitoring compared to casual clinic measurement reduce blood pressure variability and subsequent sample size requirements for clinical trials in the elderly?
Ambulatory blood pressure monitoring reduces between-subject blood pressure variability compared to casual clinic readings, which can modestly reduce sample size requirements for parallel-group clinical trials in the elderly.
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ABPM may modestly reduce sample sizes for elderly hypertension trials; leaves open confirmation in randomized designs.
Silagy et al. (1992) studied this question.
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