Why the study?
Do longitudinal and postural changes in blood pressure predict incident dementia in a general population?
Population
18,240 participants from the prospective population-based Malmö Preventive Project, mean age 45 ± 7 years…
Comparison
Extreme decrease in systolic/diastolic blood… vs Reference group characterised by pronounced…
Design
Cohort
Follow-up
Baseline 1974-1992 to Dec 31, 2009
Authors
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Postural DBP drop and BP decline from midlife were associated with higher dementia risk; leaves open whether BP trajectories modify incidence in observational data.
Do longitudinal and postural changes in blood pressure predict incident dementia in a general population?
Diastolic blood pressure decrease on standing in middle age, and longitudinal blood pressure decline between middle and advanced age, are independent risk factors for developing dementia.
Holm et al. (2017) studied this question.
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