Why the study?
Does viral IL-10 gene transfer reduce the severity of collagen-induced arthritis in DBA/1 mice?
Population
DBA/1 mice with collagen-induced arthritis
Design
Preclinical
Authors
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Prophylactic vIL-10 gene transfer attenuates murine CIA; leaves open translation to humans and utility in established disease.
Does viral IL-10 gene transfer reduce the severity of collagen-induced arthritis in DBA/1 mice?
Viral IL-10 gene transfer can delay onset and reduce severity of collagen-induced arthritis in mice when given prophylactically, but is ineffective for established disease and elicits immune responses against the vector.
Ma et al. (1998) studied this question.
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